Rabbit Secondary Antibodies
ABclonal Technology 647 Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983])
ABclonal Technology 647 Rabbit anti-Human CR2/CD21
This gene encodes a membrane protein which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 647 Rabbit anti-Human IgE
IgE is the class of antibodies produced in the lungs skin and mucous membranes It may protect against parasite invasion but it is a major factor in allergic reactions The antigen-specific IgE interacts with mast cells and eosinophils triggers the release of histamine leukotrienes and other substances that lead to the itching sneezing and congestion of allergies - and the life threatening respiratory distress of asthma and anaphylactic shock
ABclonal Technology 647 Rabbit anti-Human CD55
This gene encodes a glycoprotein involved in the regulation of the complement cascade Binding of the encoded protein to complement proteins accelerates their decay thereby disrupting the cascade and preventing damage to host cells Antigens present on this protein constitute the Cromer blood group system (CROM) Alternative splicing results in multiple transcript variants The predominant transcript variant encodes a membrane-bound protein but alternatively spliced transcripts may produce soluble proteins
ABclonal Technology 594 Rabbit anti-Human CDCP1
This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis Alternative splicing results in multiple transcript variants of this gene
ABclonal Technology 488 Rabbit anti-Human CD35
Complement receptor type 1 (CR1 CD35) is a type I transmembrane glycoprotein that is expressed on the surface of B cells neutrophils monocytes and renal podocytes As a component of the host s innate immune system CR1 CD35 expressed on neutrophils and monocytes binds to ligands coated with complement opsonins C3b and C4b thereby promoting phagocytosis and pro-inflammatory cytokine production CR1 CD35 also participates in negative regulation of the complement cascade through its ability to promote dissociation of C3 and C5 convertases and by serving as one of multiple cofactors for factor-I-mediated cleavage and inactivation of C3b and C4b
ABclonal Technology 647 Rabbit anti-Human CD58
This gene encodes a member of the immunoglobulin superfamily The encoded protein is a ligand of the T lymphocyte CD2 protein and functions in adhesion and activation of T lymphocytes The protein is localized to the plasma membrane Alternatively spliced transcript variants have been described
ABclonal Technology 647 Rabbit anti-Human CD8b
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system The CD8 antigen acting as a coreceptor and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules The functional coreceptor is either a homodimer composed of two alpha chains or a heterodimer composed of one alpha and one beta chain Both alpha and beta chains share significant homology to immunoglobulin variable light chains This gene encodes the CD8 beta chain isoforms Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described A pseudogene also located on chromosome 2 has been identified
ABclonal Technology PE Rabbit anti-Human CD4 mAb
This gene encodes the CD4 membrane glycoprotein of T lymphocytes The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit This gene is expressed not only in T lymphocytes but also in B cells macrophages granulocytes as well as in various regions of the brain The protein functions to initiate or augment the early phase of T-cell activation and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene
ABclonal Technology APC Rabbit anti-Human CD33 mAb
CD33 a type I transmembrane protein is a sialic acid-binding Ig-like lectin (Siglec-3) of the Ig superfamily and human CD33 binds preferentially to alpha-2 6-linked sialic acid Upon binding to its ligands CD33 transduces an inhibitory signaling through the immunoreceptor tyrosine-based inhibitory motif (ITIM) in its intracellular domain inhibiting cellular function such as phagocytosis In addition CD33 is also involved in other processes such as adhesion Due to its exclusive expression on hematopoietic cells particularly the myeloid lineage and their progenitors CD33 has been actively pursued as a therapeutic target against acute myeloid leukemia (AML) CD33 may also be involved in Alzheimer s Disease
ABclonal Technology 450 Rabbit anti-Human LAMP2
The protein encoded by this gene is a member of a family of membrane glycoproteins This glycoprotein provides selectins with carbohydrate ligands It may play a role in tumor cell metastasis It may also function in the protection maintenance and adhesion of the lysosome Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins
ABclonal Technology 700 Rabbit anti-Human CD97
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors which mediate cell-cell interactions These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit which associate at the cell surface as a receptor complex The encoded protein may play a role in cell adhesion as well as leukocyte recruitment activation and migration and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55 Expression of this gene may play a role in the progression of several types of cancer Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19
ABclonal Technology 594 Rabbit anti-Human CD46
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I which protects the host cell from damage by complement In addition the encoded protein can act as a receptor for the Edmonston strain of measles virus human herpesvirus-6 and type IV pili of pathogenic Neisseria Finally the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome Alternatively spliced transcript variants encoding different isoforms have been described
ABclonal Technology 647 Rabbit anti-Human GSK3B
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily It is a negative regulator of glucose homeostasis and is involved in energy metabolism inflammation ER-stress mitochondrial dysfunction and apoptotic pathways Defects in this gene have been associated with Parkinson disease and Alzheimer disease
ABclonal Technology 647 Rabbit anti-Human TNF-a
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily This cytokine is mainly secreted by macrophages It can bind to and thus functions through its receptors TNFRSF1A TNFR1 and TNFRSF1B TNFBR This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation differentiation apoptosis lipid metabolism and coagulation This cytokine has been implicated in a variety of diseases including autoimmune diseases insulin resistance psoriasis rheumatoid arthritis ankylosing spondylitis tuberculosis autosomal dominant polycystic kidney disease and cancer Mutations in this gene affect susceptibility to cerebral malaria septic shock and Alzheimer disease Knockout studies in mice also suggested the neuroprotective function of this cytokine